Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis.

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Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis.

Stigmasterol has been shown exhibit anti-osteoarthritic properties in vitro studies. However, the in vivo effects of stigmasterol on cartilage are still unclear. This study investigated the anti-osteoarthritic properties of stigmasterol on cartilage degradation in a rabbit model of osteoarthritis (OA). Twenty rabbits underwent bilateral anterior cruciate ligament transection (ACLT) to induce OA...

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Osteoarthritis, the most common joint disease, affecting millions people world-wide, involves the degradation of the articular cartilage which provides frictionless contact between the bones in a joint during movement. To a first approximation, this tissue is composed of two components, a collagen framework and entrapped proteoglycans. The framework consists of type II collagen fibrils built on...

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ژورنال

عنوان ژورنال: Acta Biochimica Polonica

سال: 2012

ISSN: 1734-154X,0001-527X

DOI: 10.18388/abp.2012_2088